Placental transfer and maternal and fetal hemodynamic effects of ketanserin in the pregnant ewe.

نویسندگان

  • T J Schneider
  • P C Struijk
  • F K Lotgering
  • H C Wallenburg
چکیده

OBJECTIVE To determine placental transfer of ketanserin and to assess the effect of serotonin-2 receptor blockade by ketanserin on serotonin- and phenylephrine-induced vasoconstriction. STUDY DESIGN Five chronically instrumented pregnant ewes at 120 days gestation were injected with 20 mg ketanserin i.v., and fetal and maternal arterial samples were obtained at predetermined intervals to assess placental transfer. Maternal and fetal responses of blood flows and pressures were determined after injected of serotonin (20 micrograms/kg) or phenylephrine (10 micrograms/kg) before and after ketanserin (0.75 mg/kg). RESULTS In the ewe, ketanserin is transferred across the placenta and reaches measurable levels in the fetal lamb. Ketanserin blocks the maternal and fetal serotonin-induced rise in arterial pressure, but not the serotonin-induced reduction in uterine blood flow. CONCLUSION In the pregnant ewe, the serotonin-induced rise in maternal and fetal blood pressure is effectively antagonized by ketanserin, whereas the serotonin-induced reduction in uterine blood flow is not.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Propofol Pharmacokinetics and Estimation of Fetal Propofol Exposure during Mid-Gestational Fetal Surgery: A Maternal-Fetal Sheep Model.

BACKGROUND Measuring fetal drug concentrations is extremely difficult in humans. We conducted a study in pregnant sheep to simultaneously describe maternal and fetal concentrations of propofol, a common intravenous anesthetic agent used in humans. Compared to inhalational anesthesia, propofol supplemented anesthesia lowered the dose of desflurane required to provide adequate uterine relaxation ...

متن کامل

The impact of COVID-19 during pregnancy on fetal brain development

The development of the brain as the most complex structure of the human body is a long process that begins in the third week of pregnancy and continues until adulthood and even until the end of life (1). Human brain myelination begins one to two months before birth in the visual system and eventually lasts until the age of two in other sensory systems and then the motor systems (4). Processes a...

متن کامل

P-211: Quantitative Changes of Fetal DNA in Maternal Circulation during Pregnancy Based on Detection of SRY Gene in Ovine Species

Background: It is well documented that fetal DNA can cross the placenta and is present in peripheral maternal blood during pregnancy in human. This fetal DNA also named circulating cell free fetal DNA, has emerged as a valuable source for genetic evaluation. Compared with humans, ovine species have a different structure of placental (synepitheliochorial) with no direct contact between the troph...

متن کامل

P-122: Morphine Effects on Placental Layers in Wistar Rats

Background: Experiments have shown that opioid drugs abuse during pregnancy can cause a delay in the development of the placenta. In mammals, the placenta is the most important channel for the exchange of Materialss between the maternal and fetal bloods. The present study investigates the time-dependent effect of the addiction duration of maternal morphine consumption during pregnancy. Material...

متن کامل

Fetal-to-maternal transfer of 3,38,5-triiodothyronine sulfate and its metabolite in sheep

Wu, Sing-Yung, Daniel H. Polk, Wen-Sheng Huang, and Delbert A. Fisher. Fetal-to-maternal transfer of 3,38,5triiodothyronine sulfate and its metabolite in sheep. Am. J. Physiol. 277 (Endocrinol. Metab. 40): E915–E919, 1999.— Earlier studies have shown that sulfoconjugation is a major pathway of thyroid hormone metabolism in fetal mammals. To assess the placental transfer of sulfoconjugates in th...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • European journal of obstetrics, gynecology, and reproductive biology

دوره 68 1-2  شماره 

صفحات  -

تاریخ انتشار 1996